{"id":811,"date":"2026-03-02T11:29:55","date_gmt":"2026-03-02T16:29:55","guid":{"rendered":"https:\/\/coefs.charlotte.edu\/iyang3\/?page_id=811"},"modified":"2026-03-02T11:54:29","modified_gmt":"2026-03-02T16:54:29","slug":"bioelectronic-medicine-neural-activity-dependent-myelination-by-electrical-optogenetic-and-magnetic-stimulation","status":"publish","type":"page","link":"https:\/\/coefs.charlotte.edu\/iyang3\/research\/bioelectronic-medicine-neural-activity-dependent-myelination-by-electrical-optogenetic-and-magnetic-stimulation\/","title":{"rendered":"Bioelectronic Medicine: Neural-Activity Dependent myelination by Electrical, Optogenetic, and Magnetic Stimulation"},"content":{"rendered":"\n

Demyelination is a disease status of the nervous system in which the myelin sheath of neurons is damaged. Stimulation has been proven to result in “Activity-Based Recovery”; a method of myelin regeneration by electrical, magnetic, and optogenetic means. Using an in-vitro <\/em>model paired with a microfluidic device, different methods of stimulation were tested to show neural regeneration.<\/p>\n\n\n\n

 <\/p>\n\n\n\n

In Vitro Model of Electrical Stimulation for Myelination:<\/strong><\/p>\n\n\n\n

<\/p>\n\n\n\n

Electrical stimulation at the stoma, axons, or both will all result in myelin regeneration. However, axon stimulation seems to be the most effective.
<\/strong><\/p>\n\n\n\n

\"Oligodendrocytes\"
Oligodendrocytes, the cells that produce the myelin sheath, were observed to measure levels of maturation in the In Vitro model.<\/figcaption><\/figure>\n\n\n\n
\"electron<\/figure>\n\n\n\n
\"myelin<\/figure>\n\n\n\n
\"Electrical
Electrical stimulation at the stoma, axons, or both will all result in myelin regeneration. However, axon stimulation seems to be the most effective. <\/figcaption><\/figure>\n\n\n\n

Optogenetic Stimulation:<\/strong><\/p>\n\n\n\n

Optogenetic stimulation uses light to stimulate neurons. Similar to electrical stimulation, this method is used to stimulate oligodendrocytes, thus regenerating the myelin sheath. This method is used as a less invasive technique for neural regeneration.<\/p>\n\n\n\n

<\/p>\n\n\n\n

\"carbon
Carbon Black PDMS was sued to create a lightproof micro-fluidic device.<\/figcaption><\/figure>\n\n\n\n

<\/p>\n\n\n\n

\"LED<\/figure>\n\n\n\n

<\/p>\n\n\n\n

LED optogenetic <\/a><\/strong><\/p>\n\n\n\n

<\/p>\n\n\n\n

Magnetic Stimulation:<\/strong><\/p>\n\n\n\n

Magnetic stimulation is a non-invasive stimulation method for myelin regeneration. Also known as TMS, magnetic stimulation has been shown to stimulate neurons, and is currently being used as a therapy method for mental health disorders.<\/p>\n\n\n\n

\"TMS\"<\/figure>\n\n\n\n

<\/p>\n\n\n\n

Most TMS devices are very large and require incredible power in order to function, the purpose of this research is to create a handheld device that can be used as a magnetic stimulator, using a biometric low-intensity magnetic field for tissue activation.<\/p>\n\n\n\n

\"TMS<\/figure>\n\n\n\n

<\/p>\n\n\n\n

\"image2\"<\/figure>\n\n\n\n

<\/p>\n\n\n\n

The next phase of this project is to create a flexible device that could be directly implanted (in vivo<\/em>) onto a nerve to have more accuracy and better results for neural stimulation.<\/p>\n\n\n\n

\"flexible<\/figure>\n\n\n\n
\"image1\"<\/figure>\n\n\n\n
\"main<\/figure>\n\n\n
\n
\"common<\/figure>\n<\/div>","protected":false},"excerpt":{"rendered":"

Demyelination is a disease status of the nervous system in which the myelin sheath of neurons is damaged. Stimulation has been proven to result in “Activity-Based Recovery”; a method of myelin regeneration by electrical, magnetic, and optogenetic means. Using an … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":14,"featured_media":0,"parent":169,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-811","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/PaHwBx-d5","_links":{"self":[{"href":"https:\/\/coefs.charlotte.edu\/iyang3\/wp-json\/wp\/v2\/pages\/811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/coefs.charlotte.edu\/iyang3\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/coefs.charlotte.edu\/iyang3\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/coefs.charlotte.edu\/iyang3\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/coefs.charlotte.edu\/iyang3\/wp-json\/wp\/v2\/comments?post=811"}],"version-history":[{"count":5,"href":"https:\/\/coefs.charlotte.edu\/iyang3\/wp-json\/wp\/v2\/pages\/811\/revisions"}],"predecessor-version":[{"id":824,"href":"https:\/\/coefs.charlotte.edu\/iyang3\/wp-json\/wp\/v2\/pages\/811\/revisions\/824"}],"up":[{"embeddable":true,"href":"https:\/\/coefs.charlotte.edu\/iyang3\/wp-json\/wp\/v2\/pages\/169"}],"wp:attachment":[{"href":"https:\/\/coefs.charlotte.edu\/iyang3\/wp-json\/wp\/v2\/media?parent=811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}